Diabetes and amyloid

Reading about amyloid plaques maybe causing diabetes (LINK) ...  Very interesting.  I may add it to the book after I digest it.  By the way, Science Daily is an excellent free on-line resource for researching any science topic.  It provides hyperlinks to related articles and reports on all significant developments in all scientific fields.  The articles are readable but not dumbed down.

Lysosome Exocytosis

What happens to to lysosomes?  Do they stay around forever or do they eventually break up?  What do they do with stuff they cannot digest?  In looking for answers to these questions, I've come across reports that lysosomes participate in exocytosis to repair the cell membrane when it is broken http://www.pnas.org/content/101/48/16795.full .  If lysosomes routinely exocytose then that could answer some of my questions.  Perhaps they exocytose when they have fully digested their contents and thereby dump any undigestibles and disappear quietly.  This might explain how the aggregate proteins in AD appear as plaques outside the cell as well as within.  I may also explain how aggregate proteins could move to other cells to seed new mis-folding cascades.

Protein Cycling Diet

This site is for those who read my book Protein Cycling Diet availablein updated hypertext at http://knol.google.com/k/ron-mignery/protein-cycling-diet/2s3nmvrwklbxs/1?domain=knol.google.com&locale=en.  In this blog, they can read about developments in the field and the views and experiences of others as well as post their own.  The book is also available in paper and ink form at http://www.lulu.com/content/5429773 

though the book is still evolving and the printed form may not be current.

It is a monograph for a general audience on a diet that has the potential to delay the onset and progression of neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's and ALS. It is written from a biomedical perspective and is based on recent findings in the field suggesting that periodic protein restriction can induce autophagy, a process by which cells can clear out the protein aggregates thought responsible for disease symptoms.

Protein Cycling is intended as a way for you to live longer and healthier with minimal interference with your normal routine and diet. It is based on well-established observations that animals and people who have endured periods of famine have extended life spans compared to those who have not and on more recent observations that periodic protein restriction alone can accomplish the same thing.