Diabetes and amyloid

Reading about amyloid plaques maybe causing diabetes (LINK) ...  Very interesting.  I may add it to the book after I digest it.  By the way, Science Daily is an excellent free on-line resource for researching any science topic.  It provides hyperlinks to related articles and reports on all significant developments in all scientific fields.  The articles are readable but not dumbed down.

Lysosome Exocytosis

What happens to to lysosomes?  Do they stay around forever or do they eventually break up?  What do they do with stuff they cannot digest?  In looking for answers to these questions, I've come across reports that lysosomes participate in exocytosis to repair the cell membrane when it is broken http://www.pnas.org/content/101/48/16795.full .  If lysosomes routinely exocytose then that could answer some of my questions.  Perhaps they exocytose when they have fully digested their contents and thereby dump any undigestibles and disappear quietly.  This might explain how the aggregate proteins in AD appear as plaques outside the cell as well as within.  I may also explain how aggregate proteins could move to other cells to seed new mis-folding cascades.